Jennifer DuBois disclaims that Cartwheel is “loosely inspired by the story of Amanda Knox.” DuBois mirrors facts of the Knox case in her own plot: when the young, beautiful American Lily is accused of murdering her roommate in Buenos Aires, her DNA is on the knife and the bra strap, there’s a local boyfriend, and a job at a bar recently lost. And there is, of course, the cartwheel, which Lily does during a break between interviews just after her roommate’s death.